Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (Admin Supp)

FULL PROPOSAL: The publication of reliable analytical methods for quantitative determination of chemical constituents of natural products and dietary supplements can make critical contributions to the rigor and reproducibility of biomedical research. In order to support formal validation studies and publication of relevant quantitative analytical chemistry methods, Administrative Supplements to certain active awards administered by the participating ICs are available through this FOA.  The methods proposed for validation must be used to identify and quantify chemical constituents (active or marker chemical compounds, adulterants, contaminants, or metabolites thereof) in experimental reagents, raw materials, and/or clinical specimens (for example urine or plasma samples). Methods must have been developed or utilized in fulfillment of the active parent grant’s specific aims. Candidate constituents for quantitative method validation studies may include (but are not limited to):  phytochemicals; nutrients; and potentially deleterious substances such as pesticides and mycotoxins.