Letter of intent (full proposal due 5/24/2017). The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this National Institute of Biomedical Imaging and Bioengineering (NIBIB) R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Research Experiences and Mentoring Activities for underrepresented undergraduate freshmen and sophomores in a science, technology, engineering, or mathematics (STEM) field, especially those fields which broadly impact bioengineering. The ESTEEMED program is intended to support underrepresented racial and ethnic groups, individuals with disabilities, and individuals from disadvantaged backgrounds. It will prepare these participants for an Advanced Honors Program, such as a MARC U-STAR (T34) program and institutional program with similar goals, in the junior and senior years and subsequently, to pursue a Ph.D. or M.D./Ph.D. degree and a biomedical research career in academia or industry.