Fish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms.

TitleFish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms.
Publication TypeJournal Article
Year of Publication2021
AuthorsKemp, DC, Kwon, JYeon
Date Published2021 May 27
KeywordsAmino Acids, Animals, Anti-Inflammatory Agents, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, DNA Damage, Extracellular Signal-Regulated MAP Kinases, Fishes, Hydrophobic and Hydrophilic Interactions, Inflammation, Macrophages, MAP Kinase Kinase 4, Molecular Weight, NF-KappaB Inhibitor alpha, Oxidative Stress, p38 Mitogen-Activated Protein Kinases, Peptides, Reproducibility of Results, Shellfish, Shellfish Proteins

The interest in utilizing food-derived compounds therapeutically has been rising. With the growing prevalence of systematic chronic inflammation (SCI), efforts to find treatments that do not result in the side effects of current anti-inflammatory drugs are underway. Bioactive peptides (BAPs) are a particularly promising class of compounds for the treatment of SCI, and the abundance of high-quality seafood processing byproducts (SPB) makes it a favorable material to derive anti-inflammatory BAPs. Recent research into the structural properties of anti-inflammatory BAPs has found a few key tendencies including they tend to be short and of low molecular weight (LMW), have an overall positive charge, contain hydrophobic amino acids (AAs), and be rich in radical scavenging AAs. SPB-derived anti-inflammatory BAPs have been observed to work via inhibition of the NF-κB and MAPK pathways by disrupting the phosphorylation of IκBα and one or more kinases (ERK, JNK, and p38), respectively. Radical scavenging capacity has also been shown to play a significant role in the efficacy of SPB-derived anti-inflammatory BAPs. To determine if SPB-derived BAPs can serve as an effective treatment for SCI it will be important to understand their properties and mechanisms of action, and this review highlights such findings in recent research.

Alternate JournalMolecules
PubMed ID34072134
PubMed Central IDPMC8198112