TitleIntegrating zebrafish toxicology and nanoscience for safer product development.
Publication TypeJournal Article
Year of Publication2013
AuthorsKim, K-T, Tanguay, RL
JournalGreen Chem
Volume15
Issue4
Pagination872-880
Date Published2013 Apr 01
ISSN1463-9262
Abstract

The design, manufacture and application of safer products and manufacturing processes have been important goals over the last decade and will advance in the future under the umbrella of "Green Chemistry". In this review, we focus on the burgeoning diversity of new engineered nanomaterials (ENMs) and the prescient need for a nanotoxicology paradigm that quickly identifies potentially hazardous nanochemistries. Advances in predictive toxicological modeling in the developing zebrafish offer the most immediate translation to human hazard that is practically achievable with high throughput approaches. Translation in a vertebrate model that is also a low cost alternative to rodents for hazard prediction has been a desirable but elusive testing paradigm. The utility of zebrafish, if applied early in the ENM discovery pipeline, could greatly enhance efforts toward greener and more efficient nanoscience. Early pipeline detection of human and environmental health impacts will quickly inform decisions in the design and production of safer commercial ENMs.

DOI10.1039/C3GC36806H
Alternate JournalGreen Chem
PubMed ID23772181
PubMed Central IDPMC3680127
Grant ListR01 ES016896 / ES / NIEHS NIH HHS / United States