College of Agricultural Sciences

E. F. ’ Donnell, Kopparapu, P. Rao, Koch, D. C., Jang, H. Sang, Phillips, J. Lynne, Tanguay, R. L., Kerkvliet, N. I., and Kolluri, S., “The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells”, PLoS ONE, vol. 7, no. 7, p. e40926, 2012.

E. F. O'Donnell, Koch, D. C., Bisson, W. H., Jang, H. S., and Kolluri, S., “The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells”, Cell death & disease, vol. 5, p. e1038, 2014.

S. Punj, Kopparapu, P., Jang, H. Sang, Phillips, J. Lynne, Pennington, J. M., Rohlman, D., O'Donnell, E. F., Iversen, P. L., Kolluri, S., and Kerkvliet, N. I., “Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease.”, PLoS One, vol. 9, no. 2, p. e88726, 2014.

C. V. Gerlach, Das, S. R., Volz, D. C., Bisson, W. H., Kolluri, S., and Tanguay, R. L., “Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish”, Aquatic Toxicology, vol. 154, pp. 71 - 79, 2014.

C. V. Gerlach, Das, S. R., Volz, D. C., Bisson, W. H., Kolluri, S. K., and Tanguay, R. L., “Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish.”, Aquat Toxicol, vol. 154, pp. 71-9, 2014.

C. V. Gerlach, Das, S. R., Volz, D. C., Bisson, W. H., Kolluri, S., and Tanguay, R., “Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish”, Aquatic Toxicology, vol. 154, pp. 71–79, 2014.

A. Perkins, Phillips, J. Lynne, Kerkvliet, N. I., Tanguay, R. L., Perdew, G. H., Kolluri, S. K., and Bisson, W. H., “A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain.”, Biology (Basel), vol. 3, no. 4, pp. 645-69, 2014.

A. Perkins, Phillips, J. Lynne, Kerkvliet, N. I., Tanguay, R., Perdew, G. H., Kolluri, S., and Bisson, W. H., “A structural switch between agonist and antagonist bound conformations for a ligand-optimized model of the human aryl hydrocarbon receptor ligand binding domain”, Biology, vol. 3, pp. 645–669, 2014.

A. Perkins, Phillips, J. Lynne, Kerkvliet, N., Tanguay, R., Perdew, G., Kolluri, S., and Bisson, W. H., “A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain”, Biology, vol. 399, no. 4, pp. 645 - 669, 2014.

D. C. Koch, Jang, H. S., O'Donnell, E. F., Punj, S., Kopparapu, P. R., Bisson, W. H., Kerkvliet, N. I., and Kolluri, S., “Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1.”, Oncogene, 2015.

A. K. Ehrlich, Pennington, J. M., Wang, X., Rohlman, D., Punj, S., Löhr, C. V., Newman, M. T., Kolluri, S., and Kerkvliet, N. I., “Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice.”, J Immunol, vol. 196, no. 1, pp. 264-73, 2016.

A. K. Ehrlich, Pennington, J. M., Tilton, S., Wang, X., Marshall, N. B., Rohlman, D., Funatake, C., Punj, S., O'Donnell, E. F., Yu, Z., Kolluri, S., and Kerkvliet, N. I., “AhR activation increases IL-2 production by alloreactive CD4 T cells initiating the differentiation of mucosal-homing Tim3 Lag3 Tr1 cells.”, Eur J Immunol, vol. 47, no. 11, pp. 1989-2001, 2017.

E. F. O'Donnell, Jang, H. Sang, Pearce, M. C., Kerkvliet, N. I., and Kolluri, S., “The aryl hydrocarbon receptor is required for induction of p21cip1/waf1 expression and growth inhibition by SU5416 in hepatoma cells.”, Oncotarget, vol. 8, no. 15, pp. 25211-25225, 2017.

H. Sang Jang, Pearce, M. C., O'Donnell, E. F., Nguyen, B. Duc, Truong, L., Mueller, M. J., Bisson, W. H., Kerkvliet, N. I., Tanguay, R. L., and Kolluri, S., “Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells.”, Biology (Basel), vol. 6, no. 4, 2017.

H. Jang, Pearce, M. C., O'Donnell, E. F., Nguyen, B., Truong, L., Mueller, M. J., Bisson, W. H., Kerkvliet, N. I., Tanguay, R. L., and Kolluri, S., “Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells”, Biology (Basel), vol. 6, no. 4, 2017.

S. Kolluri, Jin, U. - H., and Safe, S., “Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.”, Arch Toxicol, vol. 91, no. 7, pp. 2497-2513, 2017.

M. C. Pearce, Gamble, J. T., Kopparapu, P. R., O'Donnell, E. F., Mueller, M. J., Jang, H. Sang, Greenwood, J. A., Satterthwait, A. C., Tanguay, R. L., Zhang, X. -kun, and Kolluri, S., “Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells.”, Oncotarget, vol. 9, no. 40, pp. 26072-26085, 2018.

A. K. Ehrlich, Pennington, J. M., Bisson, W. H., Kolluri, S., and Kerkvliet, N. I., “TCDD, FICZ, and other high affinity AhR ligands dose-dependently determine the fate of CD4+ T cell differentiation.”, Toxicol Sci, 2018.