FULL PROPOSAL: The BMMB Program supports fundamental research in biomechanics and mechanobiology. An emphasis is placed on multiscale mechanics approaches in the study of organisms that integrate across molecular, cell, tissue, and organ domains. The influenceof in vivomechanical forces on cell and matrix biology in the histomorphogenesis, maintenance, regeneration, and aging of tissues is an important concern. In addition, the relationships between mechanical behavior and extracellular matrix composition and organization are of interest. Funded projects may include theoretical, computational, and experimental approaches. The program encourages the consideration of diverse living tissues as smart materials that are self-designing.