We are seeking short, non-confidential proposals that describe a plan to demonstrate the transfer of and expression from large fungal biosynthetic gene clusters in a heterologous fungal (yeast or filamentous fungi) host, leading to detectable production of natural products.
A heterologous fungal (yeast or filamentous fungi) expression system capable of producing natural products from various classes: e.g., non-ribosomal peptide, polyketide, terpenoids, etc.
Demonstrated success in the transfer of and expression from fungal biosynthetic gene clusters comprised of >5 genes to a heterologous fungal host system
Demonstrated success in the heterologous production of a natural product from at least one class
Openness to jointly identify target GBCs with Corteva scientists, if your proposal is selected