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Siva Kolluri
siva.kolluri [at] oregonstate.edu
Office: 541-737-1799
Research Focus:
Our laboratory has expertise in the investigation of biological activity of chemical compounds and their mechanisms of action. Research in the Kolluri laboratory includes investigation of the pathways regulating cell cycle, cell death and differentiation.
Currently, the Kolluri laboratory is investigating Aryl hydrocarbon Receptor (AhR)-mediated pathways that regulate anti-cancer functions. We have discovered and developed a new class of compounds termed as “Select Modulators of AhR-regulated Transcription” (SMAhRTs). SMAhRTs are effective against certain cancers including triple negative breast cancers, which account for about 15% of breast cancers with the worst prognosis. The Kolluri laboratory is elucidating the molecular mechanisms of SMAhRT-induced anti-cancer effects mediated by AhR signaling.
The Kolluri laboratory is also investigating mechanisms of therapeutic resistance in cancers. Human cancers express Bcl-2, a protein that gives survival advantage to cancer cells. Increased expression of this protein allows the cancer cells to resist chemotherapy treatments and survive. We have an invention to change Bcl-2 from a cancer protective to a cancer destructive protein and have developed ‘first-in-class’ small molecules that change Bcl-2 into a cancer cell killer. The Kolluri laboratory is investigating the therapeutic utility of this innovation in cancers.
Recent publications from our laboratory:
1. Kopparapu PR, Pearce MC, Löhr CV, Duong C, Jang HS, Tyavanagimatt S, O'Donnell EF, Nakshatri H, Kolluri SK. Identification and characterization of a small molecule Bcl-2 Functional Converter. Cancer Res Commun. 2024 Feb 8. doi: 10.1158/2767-9764.CRC-22-0526.
2. Elson DJ, Nguyen BD, Korjeff NA, Wilferd SF, Puig-Sanvicens V, Sang Jang H, Bernales S, Chakravarty S, Belmar S, Ureta G, Finlay D, Plaisier CL, Kolluri SK. Suppression of Ah Receptor (AhR) increases the aggressiveness of TNBC cells and 11-Cl-BBQ-activated AhR inhibits their growth. Biochem Pharmacol. 2023 Sep;215:115706. doi: 10.1016/j.bcp.2023.115706.
3. Elson DJ, Nguyen BD, Bernales S, Chakravarty S, Jang HS, Korjeff NA, Zhang Y, Wilferd SF, Castro DJ, Plaisier CL, Finlay D, Oshima RG, Kolluri SK. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacolology and Translational Science. 2023 Jun 7;6(7):1028-1042. doi: https://doi.org/10.1021/acsptsci.2c00253
4. Elson DJ, Kolluri SK. Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer. Biology (Basel). 2023 Mar 30;12(4):526. doi: 10.3390/biology12040526.
5. Nguyen BD, Stevens BL, Elson DJ, Finlay D, Gamble JT, Kopparapu PR, Tanguay RL, Buermeyer AB, Kerkvliet NI, Kolluri SK. 11-Cl-BBQ, a select modulator of AhR-regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27Kip1. FEBS J. 2023 Apr;290(8):2064-2084. doi: 10.1111/febs.16683
6. Phillips JL, Löhr CV, Nguyen BD, Buermeyer AB, Kolluri SK. Loss of the aryl hydrocarbon receptor increases tumorigenesis in p53-deficient mice. Toxicol Appl Pharmacol. 2022 Nov 1;454:116191. doi: 10.1016/j.taap.2022.116191.
7. Elson DJ, Nguyen BD, Wood R, Zhang Y, Puig-Sanvicens V, Kolluri SK. The cyclin-dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity. FEBS Lett. 2022 Aug;596(16):2056-2071. doi: 10.1002/1873-3468.14434.
8. O'Donnell EF 3rd, Jang HS, Liefwalker DF, Kerkvliet NI, Kolluri SK. Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects. Apoptosis. 2021;26(5-6):307-322. doi: 10.1007/s10495-021-01666-0.
https://factor.niehs.nih.gov/2021/6/papers/cancer-fighting-compounds/index.htm
https://link.springer.com/article/10.1007/s10495-021-01666-0
https://link.springer.com/article/10.1007/s10495-021-01672-2
Conversion of Bcl-2 from a protector to a killer in cancer cells: A major goal of our laboratory is to identify small molecules that convert Bcl-2 from a protector to a killer protein, establish their therapeutic efficacy in various cancer models and move these ‘first-in-class’ cancer therapeutics to the clinic and help cancer patients.
Bcl-2-family proteins are evolutionarily conserved regulators of cell death. The Bcl-2 family primarily acts on mitochondria to regulate cell death. Overexpression of Bcl-2 contributes to cancer development and tumor progression by blocking pro-cell death Bcl-2 family members. The overexpression of Bcl-2 correlates with poor survival and correlates with resistance of cancer cells to many chemotherapeutic drugs and radiation.
We discovered a novel pathway in which Bcl-2 is converted from a protector to a killer protein (Cell 116, 527-540, 2004; Cancer Cell, 14:285-98, 2008; Oncotarget, 9:26072-26085, 2018; Apoptosis, 24:1-2, 2019; Apoptosis 24:529-537, 2019; Cancer Research Communications, 4:634-644, 2024; ACS Pharmacol Transl Sci., 7:1302-1309, 2024). The dramatic change in Bcl-2 function is brought about by orphan nuclear receptor Nur77 binding, which exposes a hidden ‘killer BH3 domain’ of Bcl-2. We reported the identification of a Nur77-derived Bcl-2-converting peptide with 9 amino acids (NuBCP-9) and its enantiomer, which induce apoptosis of cancer cells in vitro and in animals. The apoptotic effect of NuBCPs are not inhibited but rather potentiated by Bcl-2 expression. NuBCP-9 and its enantiomer bound to the Bcl-2 loop, which shares the characteristics of structurally adaptable regions with many cancer-associated and signaling proteins. This discovery enabled extremely exciting new research possibilities, providing a molecular basis for the design and development of novel cancer therapeutics.
Oregon State University researchers discover novel way to make breast cancer cells die
https://today.oregonstate.edu/news/oregon-state-university-researchers-discover-novel-way-make-breast-cancer-cells-die
Cancer protector into killer: https://extension.oregonstate.edu/news/osu-helps-turn-cancer-protector-killer
Cancer therapeutics based on BCL-2 functional conversion. https://link.springer.com/article/10.1007%2Fs10495-018-1504-5
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Postdoctoral Positions
NIH-NIEHS funded postdoctoral training grant positions are available for immediate appointment.
Candidates who will be graduating soon or who have received PhD in the last five years and have interests in broad areas of toxicology, molecular biology, or cell signaling, please contact Siva Kolluri ([email protected]; @ phone no. 541-737-1799).
The appointees will have an opportunity of collaborating with multiple PIs across the OSU campus, Pacific Northwest National Laboratory (PNNL) and Oregon Health & Science University (OHSU) and also pursue their own research interests.
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Ah Receptor as a therapeutic target in cancer: Ah receptor (AhR) is a ligand activated transcription factor belonging to the basic-helix-loop-helix (bHLH)-Per-Arnt-Sim (PAS) protein family. The bHLH/PAS family proteins are heterodimeric transcription factors that sense and respond to external or physiological signals such as hypoxia and circadian rhythms.
AhR has been implicated as a tumor suppressor and continues to gain interest as a viable therapeutic target in cancer. We have reported that high AhR expression is associated with increased relapse-free survival and distant metastasis free survival in patients with hormone independent breast cancer. The major focus of our laboratory is to (i) investigate AhR signaling in tumor suppression and (ii) characterize the mechanism of action of Select Modulators of AhR-regulated Transcription with anti-cancer effects (ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042. doi: 10.1021/acsptsci.2c00253; Biochem Pharmacol. 2023 Sep;215:115706. doi: 10.1016/j.bcp.2023.115706; FEBS J. 2023 Apr;290(8):2064-2084. doi: 10.1111/febs.16683; Biology (Basel). 2023 Mar 30;12(4):526. doi: 10.3390/biology12040526; Apoptosis, 2021. https://doi.org/10.1007/s10495-021-01666-0; https://doi.org/10.1007/s10495-021-01672-2).
We have developed AhR ligand binding pocket models to understand AhR ligand binding pocket interactions with distinct classes of chemical compounds. We have generated new mouse models to understand AhR mediated tumor suppression in the context of p53 tumor suppressor gene deletion (in collaboration with Dr. Christiane Loehr at OSU; Toxicol Appl Pharmacol. 2022 Nov 1;454:116191. doi: 10.1016/j.taap.2022.116191).
We are also investigating AhR mediated signaling in the immune system (in collaboration with Dr. Nancy Kerkvliet; PLoS One, 9:e88726, 2014; Journal of immunology, 196: 264-732016, 2016; Eur J Immunol., 47:1989-2001, 2017), in zebrafish (in collaboration with Dr. Robyn Tanguay) and we are examining the required properties of select AhR modulators that activate the anti-cancer actions of the AhR (Cell Death Dis., 5:e1038, 2014; Oncogene, 34:6092-104, 2015; Oncotarget, 8:25211-25225, 2017; Arch Toxicol. 91:2497-2513, 2017; Biology, 6: 2017; Apoptosis, 2021. https://doi.org/10.1007/s10495-021-01666-0; https://doi.org/10.1007/s10495-021-01672-2; ).
Osteoporosis drug for treatment of breast and liver cancers: https://www.niehs.nih.gov/news/newsletter/2014/4/science-osteoporosisdrug/
New chemical to prevent Type 1 diabetes: http://oregonstate.edu/ua/ncs/archives/2016/jan/new-chemical-could-yield-therapy-prevent-type-1-diabetes
We have discovered highly AhR selective ligands for treatment of certain breast cancers, Type 1 diabetes and are in the process of optimizing therapeutic leads for clinical translation.
Hypoxia-inducible Factor as a Target for Cancer Therapy: A major strategy in developing new cancer chemotherapeutics is to identify and target biological processes that differ between normal and malignant cells. Hypoxia, a reduction in the normal level of oxygen in tissue, occurs during cancer progression. Tumors become hypoxic because their new blood vessels are abnormal and they outgrow their blood supply. Cancer cells undergo genetic and adaptive changes that allow them to survive and proliferate in a hypoxic environment. These processes contribute to malignancy and aggressive tumor behavior.
Hypoxia inducible factor 1 (Hif-1) is a key protein factor induced by hypoxia and is involved in determining the levels of many protein factors in cancer cells. Vascular endothelial growth factor (VEGF), which promotes new blood vessel growth in tumors, is one of the important genes induced by Hif-1. Other genes regulated by Hif-1 activation are expressed at higher levels in cancer cells than in their normal tissue counterparts, and have roles in progression cancer. Hif-1 activity is also correlated with poor response to radiation therapy and chemotherapy. Our laboratory is interested in identifying pathways that disrupt Hif-1signaling in cancer cells in order to develop novel cancer therapeutics.
Sci Rep. 10(1):727 (2020)
https://pubmed.ncbi.nlm.nih.gov/31959767/
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Education:
Post Doctoral Research
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.
Mentor: Professor Xiao-kun Zhang
Ph.D. - Magna Cum Laude
The Institute of Genetics, Forschungszentrum Karlsruhe, Germany
(Director: Professor Peter Herrlich)
Thesis Mentor: Professor Martin Göttlicher
Master of Technology (Bio-Technolgy)
Jadavpur University, Calcutta, India
Bachelor of Pharmacy (Hons.)
Biria Institute of Technology and Science, Pilani, India
Honors:
National Merit Scholar
University Gold Medal, Jadavpur University, Calcutta, India
Department of Defense Breast Cancer Research Program Post-doctoral Scholar
New Investigator Award of the California Tobacco Related Disease Research Program
American Cancer Society Research Scholar
Professional Affiliations:
Cancer Prevention and Intervention Program, Linus Pauling Institute, Oregon State University
Department of Biomedical Sciences, Oregon State University
Department of Biochemistry & Biophysics, Oregon State University
Patents
Siva Kumar Kolluri, Nancy I. Kerkvliet et al., Aryl Hydrocarbon Receptor Activators. 2022.
Kolluri, S.K., Kopparapu, P; Pearce, M. Bcl-2 functional converters. 2022.
Nancy I. Kerkvliet and Siva Kumar Kolluri. Compounds and Methods to suppress autoimmune response. Patent No. # US10308649B2, 2019;
Nancy I. Kerkvliet and Siva Kumar Kolluri. Compounds and Methods to suppress autoimmune response. European patent application: EP15855322.2
Nancy I. Kerkvliet and Siva Kumar Kolluri. Compounds and Methods to suppress autoimmune response. Application No. PCT/US15/57873; 15855322.2 (European application 2017); 15/522,241 (U.S. application 2017)
Satterthwait, A., Zhang, X.K, Zhu, X., and Kolluri, S.K. Methods of regulating apoptosis. Patent No. # US20100292145A1, 2010.
Kolluri, S.K., Zhu, X., Zhang, X., and Satterthwait, A. Targeting Bcl-2 family proteins with cell-permeable peptides. US Patent No. # 20070054863, 2008.
Reed, J.C., Zhang, X., Gao, B., Lin, B. and Kolluri, S.K. Bcl-2 Converters for Cancer. US Patent No. # 6,994,979, 2006.
Göttlicher, M., Kolluri, S.K., and Weiss, C. Method for producing agents for treating tumor diseases and for immunosuppression Patent No. # US 6,482,610 B1, 2002.
Göttlicher, M., Kolluri, S.K., and Weiss, C. Method for evaluation of toxicity of environmental pollutants. Patent No. # Europe 198 11 326, 1999.
Select Publications: Citations >6300
https://scholar.google.com/citations?user=sZFSc3cAAAAJ&hl=en
Kopparapu PR, Pearce MC, Löhr CV, Duong C, Jang HS, Tyavanagimatt S, O'Donnell EF, Nakshatri H, Kolluri SK. Identification and characterization of a small molecule Bcl-2 Functional Converter. Cancer Res Commun. 2024. 4(3):634-644. PMID: 38329389.
Kopparapu PR, Löhr CV, Pearce MC, Tyavanagimatt S, Nakshatri H, Kolluri SK. Small Molecule Functional Converter of B-Cell Lymphoma-2 (Bcl-2) Suppresses Breast Cancer Lung Metastasis. ACS Pharmacol Transl Sci. 2024. 7(5):1302-1309. PMID: 38751629.
Elson DJ, Nguyen BD, Korjeff NA, Wilferd SF, Puig-Sanvicens V, Sang Jang H, Bernales S, Chakravarty S, Belmar S, Ureta G, Finlay D, Plaisier CL, Kolluri SK. Suppression of Ah Receptor (AhR) increases the aggressiveness of TNBC cells and 11-Cl-BBQ-activated AhR inhibits their growth. Biochem Pharmacol. 2023 Sep;215:115706. doi: 10.1016/j.bcp.2023.115706.
Elson DJ, Nguyen BD, Bernales S, Chakravarty S, Jang HS, Korjeff NA, Zhang Y, Wilferd SF, Castro DJ, Plaisier CL, Finlay D, Oshima RG, Kolluri SK. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacolology and Translational Science. 2023 Jun 7;6(7):1028-1042. doi: https://doi.org/10.1021/acsptsci.2c00253
Elson DJ, Kolluri SK. Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer. Biology (Basel). 2023 Mar 30;12(4):526. doi: 10.3390/biology12040526.
Nguyen BD, Stevens BL, Elson DJ, Finlay D, Gamble JT, Kopparapu PR, Tanguay RL, Buermeyer AB, Kerkvliet NI, Kolluri SK. 11-Cl-BBQ, a select modulator of AhR-regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27Kip1. FEBS J. 2023 Apr;290(8):2064-2084. doi: 10.1111/febs.16683
Phillips JL, Löhr CV, Nguyen BD, Buermeyer AB, Kolluri SK. Loss of the aryl hydrocarbon receptor increases tumorigenesis in p53-deficient mice. Toxicol Appl Pharmacol. 2022 Nov 1;454:116191. doi: 10.1016/j.taap.2022.116191.
O'Donnell EF 3rd, Jang HS, Liefwalker DF, Kerkvliet NI, Kolluri SK. Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects. Apoptosis. 2021 Apr 24. doi: 10.1007/s10495-021-01666-0. PMID: 33893898.
Gamble JT, Elson DJ, Greenwood JA, Tanguay RL, Kolluri SK. The Zebrafish Xenograft Models for Investigating Cancer and Cancer Therapeutics. Biology (Basel). 2021, 10(4):252. doi: 10.3390/biology10040252. PMID: 33804830.
Song Z, Pearce MC, Jiang Y, Yang L, Goodall C, Miranda CL, Milovancev M, Bracha S, Kolluri SK, Maier CS. Delineation of hypoxia-induced proteome shifts in osteosarcoma cells with different metastatic propensities. Scientific Reports. 10:727, 2020. PMID: 31959767.
https://www.nature.com/articles/s41598-019-56878-x
Larkey NE, Phillips JL, Jang HS, Kolluri SK, Burrows SM. Small RNA Biosensor Design Strategy To Mitigate Off-Analyte Response. ACS Sens. 5:377-384, 2020. PMID: 31942801.
https://pubs.acs.org/doi/10.1021/acssensors.9b01968
Morgan E, Gamble JT, Pearce MC, Elson DJ, Tanguay RL, Kolluri SK, Reich NO. Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery. Apoptosis. 24:529-537, 2019. PMID: 30879165. https://link.springer.com/article/10.1007%2Fs10495-019-01531-1
Pearce MC, Satterthwait AC, Zhang XK, Kolluri SK. Cancer therapeutics based on BCL-2 functional conversion. Apoptosis. 24:1-2, 2019. PMID: 30612317. https://link.springer.com/article/10.1007%2Fs10495-018-1504-5
Pearce, M.C., Gamble, J.T., Kopparapu, P.R., O’Donnell, E.F., Mueller, M.J., Jang, H.S., Greenwood, J.A., Satterthwait, A.C., Tanguay, R.L., Zhang, X.-K. and Kolluri, S.K. Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells. Oncotarget. 9: 26072–26085, 2018. PMID: 29899843
Kolluri, S.K, Jin UH, Safe S. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Arch Toxicol. 91(7):2497-2513, 2017. PMID: 28508231.
Jang, H.S.; Pearce, M.; O’Donnell, E.F.; Nguyen, B.D.; Truong, L.; Mueller, M.J.; Bisson, W.H.; Kerkvliet, N.I.; Tanguay, R.L.; Kolluri, S.K. Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells. Biology, 6, 41: 2017. PubMed PMID: 29194351.
Ehrlich AK, Pennington JM, Tilton S, Wang X, Marshall NB, Rohlman D, Funatake C, Punj S, O'Donnell E, Yu Z, Kolluri S.K, Kerkvliet NI. AhR activation increases IL-2 production by alloreactive CD4(+) T cells initiating the differentiation of mucosal-homing Tim3(+) Lag3(+) Tr1 cells. Eur J Immunol. 47:1989-2001, 2017. PMID: 28833046.
Allison K. Ehrlich, Jamie M. Pennington, Xisheng Wang, Diana Rohlman, Sumit Punj, Christiane Loehr, Matthew T. Newman, Siva K. Kolluri, and Nancy I. Kerkvliet; Activation of the Aryl Hydrocarbon Receptor Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Non-obese Diabetic Mice. Journal of immunology 196: 264-732016, 2016. PMID: 26573835.
New chemical to prevent Type 1 diabetes. http://oregonstate.edu/ua/ncs/archives/2016/jan/new-chemical-could-yield-therapy-prevent-type-1-diabetes
O'Donnell EF, Jang HS, Pearce M, Kerkvliet NI, Kolluri, S.K. The aryl hydrocarbon receptor is required for induction of p21cip1/waf1 expression and growth inhibition by SU5416 in hepatoma cells. Oncotarget. 8(15):25211-25225, 2017. PMID: 28424418.
Koch DC, Jang HS, O'Donnell EF, Punj S, Kopparapu PR, Bisson WH, Kerkvliet NI, Kolluri SK. Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. Oncogene. 34:6092-104, 2015. PMID: 25867062
O'Donnell EF, Koch DC, Bisson WH, Jang HS, Kolluri SK. The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells. Cell Death and Disease. 2014;5:e1038. doi: 10.1038/cddis.2013.549. PMID: 24481452
Osteoporosis drug for treatment of breast and liver cancers. https://www.niehs.nih.gov/news/newsletter/2014/4/science-osteoporosisdrug/
Punj S, Kopparapu P, Jang HS, Phillips JL, Pennington J, Rohlman D, O'Donnell E, Iversen PL, Kolluri SK, Kerkvliet NI. Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease. PLoS One. 2014;9(2):e88726. PMID: 24586378
Researchers discover novel compound for treat autoimmune diseases. https://www.niehs.nih.gov/news/newsletter/2014/5/science-autoimmune/index.htm
O'Donnell EF, Kopparapu PR, Koch DC, Jang HS, Phillips JL, Tanguay RL, Kerkvliet NI, Kolluri SK. The aryl hydrocarbon receptor mediates Leflunomide-induced growth inhibition of melanoma cells. PLoS ONE. 7(7): e40926, 2012.
Murray IA, Flaveny CA, Chiaro CR, Sharma AK, Tanos RS, Schroeder JC, Amin SG, Bisson WH, Kolluri SK, Perdew GH. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3', 4'-dimethoxy-{alpha}-naphthoflavone. Molecular Pharmacology. 79:508-19, 2011.
Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 17:560-73, 2010.
Bisson, W., Koch, D., O’Donnell, E., Khalil, S., Kerkvliet, N., Tanguay, R., Abagyan, R., and Kolluri, S.K. Modeling of the Aryl Hydrocarbon Receptor(AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands. Journal of Medicinal Chemistry 52:5635-41, 2009.
Kolluri SK, Zhu X, Zhou X, Lin B, Chen Y, Sun K, Tian X, Town J, Cao X, Lin F, Zhai D, Kitada S, Luciano F, O'Donnell E, Cao Y, He F, Lin J, Reed JC, Satterthwait AC, Zhang XK. A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell. 2008 Oct 7;14(4):285-98.
News and views of the above Cancer Cell article
Bing Qi & J Marie Hardwick Bcl-2 turns deadly. Nature Chemical Biology, 4: 722-23, 2008.
Martz, L. BCL-2 double take; Nature Science-Business exchange; 1(39); doi:10.1038 scibx.2008.938.
Flemming, A. New strategies to tip the BCL-2 balance. Nature Reviews Drug Discovery, 7:977, 2008.
Aschheim, K., DeFrancesco, L., and Hare, P. Flipping for apoptosis. Nature Biotechnology 26:1250, 2008.
Kolluri SK, Corr M, James SY, Bernasconi M, Lu D, Liu W, Cottam HB, Leoni LM, Carson DA, Zhang XK. The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2525-30.
Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell. 2004 Feb 20;116(4):527-40.
Kolluri SK, Bruey-Sedano N, Cao X, Lin B, Lin F, Han YH, Dawson MI, Zhang XK. Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol Cell Biol. 2003 Dec;23(23):8651-67.
Li H, Kolluri SK, Gu J, Dawson MI, Cao X, Hobbs PD, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana JA, Reed JC, Zhang X. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science. 2000 Aug 18;289(5482):1159-64.
Kolluri, SK., Balduf C., Hofmann M. and Goettlicher, M. Novel target genes of the Ah (Dioxin) receptor: transcriptional induction of N-myristoyltransferase 2. Cancer Research 61: 8534-9, 2001.
Kolluri SK, Weiss C, Koff A, Gottlicher M. p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 1999 Jul 1;13(13):1742-53.